Selected Bibliography

General

Beroza, P., Villar, H., Wick, M. W. and Martin, G. R. (2002) Chemoproteomics as a basis for post-genomic drug discovery. Drug Discovery Today, 7, 809-816.

Hoyer, D., Hannon, J. P. and Martin G. R. (2002). Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol. Biochem. Behav., 71, 533-554.

Kilpatrick, G. J., Dautzenberg, F. M., Martin, G. R. and Eglen, R. (1999) 7TM receptors: the splicing on the cake.  Trends Pharmacol Sci., 20, 294  301.

Martin, G. R. and Giles, H. (1996) Pharmacological principles for analysing responses of vascular smooth muscle. In:  Pharmacology of Vascular Smooth Muscle, Oxford University Press, Eds. Garland, C. J. and Angus, J. A., pp1-24.

Martin, G. R.  (1994). Vascular receptors for 5-hydroxytryptamine: Distribution, function and classification. Pharmacol. Ther., 62, 283-324.

Martin, G. R. and Humphrey, P. P. A. (1994)  Receptors for 5-hydroxytryptamine.  Current perspectives on classification and nomenclature.  Neuropharmacol., 33, 261-273.

Migraine

Martin, G. R. (2000) The pharmacology of zolmitriptan. In: Monographs in Clinical Neuroscience17,, Ed. Diener, H-C. pp110-115.

Martin, G. R., Rhodes, P. and Mills, A.  (1999)  Autoradiographic mapping of receptors and recognition sites for established and putative antimigraine drugs. In : Migraine and Headache Pathophysiology, Ed.  Edvinsson, L. p p 63-79.

Martin, G. R. (1998) Serotonin 5-HT_1B/D receptor agonists. In: Drugs Pharm.Sci., 89 (Receptor-Based Drug Design): pp173-194.

Martin, G. R. and Martin R. S. (1996)  Recurrent migraine following treatment with 5-HT_1D  agonists.  Pharmacokinetic and pharmacodynamic aspects. In : Migraine.  Pharmacology and Genetics, Chapman & Hall, Eds. Sandler, M., Ferrari, M. & S. Harnett, pp94-108.

Martin, G. R., Martin, R. S. and Wood J. (1995) Long-acting 5-HT_1D   receptor agonist effects of DHE. Studies using a model to differentiate slow drug-receptor dissociation from diffusion. In: Experimental Headache Models, Frontiers in Headache Research, 5, Raven Press, Eds. Olesen, J & Moskowitz, M. A., pp163-168.

Drug Discovery

Jandu K.S., Barrett, V., Brockwell, M., Cambridge, D., Farrant, D.R., Foster, C., Giles, H., Glen, R.C., Hill, A.P., Hobbs, H., Honey, A., Martin, G.R., Salmon, J., Smith, D., Woollard, P. and Selwood, D.L. (2001) Discovery of 4-[3-(trans-3-dimethylaminocyclobutyl)-1H-indol -5-ylmethyl]-(4S)-oxazolidin-2-one (4991W93), a 5HT(1B/1D) receptor partial agonist and a potent inhibitor of electrically induced plasma extravasation. J Med Chem., 44: 681-93.

Maloney, G.P., Martin, G.R., Mathews, N., Hobbs, H., Dodsworth, S., Pang, Y. S., Knight, C., Maxwell, M and Glen, R. C. (1999) Synthesis and pharmacological profile of a series of 2,5-substituted-N,N-dimethyltryptamine derivatives as novel antagonists for the vascular 5-HT_1B-like receptor. J. Chem. Soc., Perkins Trans., 1, 2713-2723.

Maloney, G.P., Martin, G.R., Mathews, N., MacLennan, S.J., Dodsworth, S., Pang, Y. S., Knight, C., Maxwell, M and Glen, R. C. (1999) Synthesis and serotonergic activity of 2-oxadiazolyl-5-substituted-N,N-dimethyltryptamines: Novel antagonists for the vascular 5-HT_1B-like receptor. J. Chem. Soc., Perkins Trans., 1, 2725-2733.

Bonhaus, D. W., Flippin, L. A., Greenhouse, R. J., Jaime, S., Rocha, C., Dawson, M., Van Nata, K., Chang, L. K., Pulido-Rios, T., Webber, A., Leung, E., Eglen, R and Martin, G. R. (1999) RS-127445: A selective, high affinity, orally bioavailable 5-HT_2B receptor antagonist. Br. J. Pharmacol., 127, 1075-1082.

Maloney, G.P., Martin, G.R., Mathews, N., Milne, A., Hobbs, H., Dodsworth, S., Pang, Y. S., Knight, C., Williams, M., Maxwell, M and Glen, R. C. (1999) Synthesis and serotonergic activity of substituted 2,N-benzylcarboxamido-5-(2-ethyl-1-dioxoimidazolidinyl) -N,N-dimethyltryptamine derivatives:  Novel antagonists for the vascular 5-HT_1B-like receptor. J.Med.Chem, 42, 2504-2526.

Martin, G.R., Robertson, A.D., MacLennan, S.J., Prentice, D.J., Barrett, V.J., Buckingham, J., Honey, A.C., Giles, H. and Moncada, S. (1997) Receptor specificity and trigemino-vascular inhibitory actions of a novel 5-HT_1D receptor partial agonist, 311C90 (Zolmitriptan).  Br. J. Pharmacol., 121, 157-164.

Glen, R. C., Martin, G. R., Hill, A. P., Hyde, R. M., Woollard, P. M., Salmon, J. A., Buckingham, J. and Robertson, A. D. (1995) Computer-aided design and synthesis of 5-substituted tryptamines and their pharmacology at the 5-HT_1D receptor: Discovery of compounds with potential anti-migraine properties.  J. Med. Chem., 38, 3566-3580.